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In Huntingtons disease (HD), hyperdopaminergiaprobably triggered by the dysfunction of the most affected neurons, indirect pathway spiny projection neurons (iSPNs)is believed to induce hyperkinesia, an early stage HD symptom

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8b), corroborating SHARP SPOC delocalization from the Barr bodies observed by immunofluorescence microscopy (Fig

10.1892/0891-6640(2005)19 2.0.co;2 22 DeGruttolaA