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QS is a bacterial communication system essential for biofilm formation, and inhibiting this system can enhance the effectiveness of antibacterial agents 108

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[] The Food and Drug Administration recognizes it as reasonably safe, [] contributing to its popularity as a dietary supplement worldwide

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However, this does not mean that EVs are perfect delivery carriers, as challenges such as large-scale production, standardization of separation techniques, and batch-to-batch reproducibility remain key obstacles for clinical translation (Wang et al., 2021)

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doi: 10.1111/j.1432-1033.2004.04067.x

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