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Dhaliwal S, Rybak I, Ellis SR, et al

More broadly, levels of pyridoxal-5-phosphate are associated with increased functional indices and biomarkers of inflammation, and levels of pyridoxal-5-phosphate are down-regulated as a function of more severe inflammation [53,54], potentially as a consequence of pyridoxal-5-phosphates role either in the metabolism of tryptophan or in one-carbon metabolism [53]

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One posited mechanism is the activation of phospholipase C (PLC), which, according to some researchers, might subsequently facilitate the release of inositol triphosphate (IP3) and diacylglycerol (DAG)

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