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However, what happens during the course of the disease remains to be elucidated, as contradictory studies in rodent models of the disease either show an abnormal expression of endogenous autophagic markers, accumulation of autophagosomes, and decreased levels of beclin-1 [86] or show no changes in these and in additional autophagy markers [88]

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doi: 10.1111/j.1365-2982.2009.01300.x

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Q16: Why isnt it widely used clinically

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Preclinical data also indicates a promising future in neuroprotection and most likely to expand its clinical utility into neurodegenerative pathologies

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