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Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

5-Amino-1MQ works differently -- it inhibits NNMT, an enzyme that diverts nicotinamide away from the NAD+ salvage pathway

Tibbetts LS, Shanelec DA

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T-CD4 + lymphocyte activation can generate some profiles (named Th), which depend on molecules present in the microenvironment

However, successful clinical translation will require addressing persistent challenges, including biosafety, biodistribution, tumor heterogeneity, and large-scale manufacturability