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Metabolically, the ACE2/Ang-(1-7)/MasR axis enhances insulin sensitivity by activating the Akt signaling pathway and modulating the ATP/P2 receptor/calmodulin signaling pathway (21)

We thank Edward Chouchani for providing protein mass spectrometry and discussions

Thiols block the angiotensin-converting enzyme 2, thereby inhibiting penetration of SARS-CoV-2 into cells

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Within these microdomains, redox-sensitive phosphatases and adaptor proteins serve as immediate sensors of radical activity, directly coupling chemical events with signaling outcomes without reliance on long-range diffusion [9]