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[DOI] [Google Scholar] 45.Zhong Z., Jones S., Thurman R

(6) The results were compared to control wounds without intervention

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In DOR-eGFP knock-in mice, the internalizing agonist, SNC-80 promotes acute tolerance to analgesia correlated with strong internalization whereas ARM-390 a non-internalizing agonist did not induce acute tolerance (Pradhan et al., Conclusions All the data presented in this review demonstrated that mechanisms of OR regulation are consistent with the model proposed by Lefkowitz (Pierce et al., Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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The drug can be administered orally, sublingually, by intramuscular injection, subcutaneous injection, or by intravenous infusion with a gradually increasing flow, until the intended target dose is achieved (Figure 5) [112]