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Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios

& Taie, H

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Tger M, Dietzmann J, Thiel U, Hinrich Neumann K, Ansorge S

By detoxifying hydrogen peroxide, catalase helps maintain sperm functionality and protects against oxidative stress-induced damage, further reinforcing the cells defense mechanisms

Accumulated ROS also activate the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome, initiating caspase-1-mediated pyroptosis and amplifying immune-mediated hepatocyte injury