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Several compounds merit further optimization as potential non-addictive analgesics: mitraciliatine and isopaynantheine as mixed MOR antagonist/KOR agonist templates, and hKOR-selective N-oxide derivatives as partial agonists that may retain antinociceptive efficacy while mitigating the dysphoria and sedation associated with full KOR activation (Carlezon et al., 2006

Kidney Int., 15: 335-345

Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain

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This is the same technique used for insulin and most other injectable peptides

Neutralizing antibodies (NAbs) to interferon beta may affect its biological availability and the production of interferon-induced biological markers (93