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Initially, the mechanisms of action of this enzyme were considered paradoxical because CD38 is predominantly localized on the cell surface, yet its final products are utilized within cytoplasmic compartments

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doi: 10.1186/s13045-020-00930-1 64 SunJMuzBAlhallakKMarkovicMGurleySWangZet al

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Andres E, Dali-Youcef N, Serraj K et al

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In addition to NAD + , CD38 also catabolizes nicotinamide mononucleotide (NMN) and other extracellular NAD + precursors prior to their intracellular transport for NAD + biosynthesis (Fig

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