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And what Ive come to the conclusion [of] and put forward [in] a new hypothesis is that if you boil down everything that happens during aging, the diseases that occur, the cellular changes that we know occur, the loss of stem cells, the senescent cells, nutrient deregulation, the telomere shortening, the ends of chromosomes getting shorter

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Cancer Cell 23 , 753767 (2013)

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GPx1 induces ROS-dependent autophagy activation under glucose deprivation conditions by affecting the redox state To explore the effect of GPx1 on the redox state, we first examined possible changes in ROS and H 2 O 2 generation and observed that the ROS and H 2 O 2 levels were higher in GPx1-knockdown PDA cells than in control cells (Fig