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In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.

This review examines the complex mechanisms underlying MTX-induced liver damage, including oxidative stress, mitochondrial impairment, inflammatory signaling pathways such as NF-B and JAK/STAT, and apoptosis

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