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Consistent with other studies in similar populations [37, 41], our finding confirmed that DAA treatment in decompensated individuals was less effective than in liver transplant recipients but still achieves SVR in a majority of cases

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Afamelanotide is FDA-approved for EPP at 16 mg subcutaneous implant every 60 days roughly 2 mg/day of continuous release (Langendonk et al., 2015)