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NF-kB, a rapidly inducible transcription factor with wide involvement in diverse cellular responses, is notably implicated in the immuno-inflammatory response in the gut, rendering it a suitable indicator for detecting various microbe-host interactions (Zhang et al., 2017)

Resveratrol activates this pathway, highlighting its potential as a supportive treatment for CRC

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Also, resveratrol acts on TAMs, promoting the M1/M2 macrophage polarization ratio, inhibiting the conversion of TAMs from M1 to M2 subtype, and exerting an inhibitory effect in the microenvironments of tumor cells in lung, breast, and oral cancers [808,809,810]

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