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Following the Morris water maze test, Nissl staining was used to observe the amount of positive neuronal cells present

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Neuroinflammation and the immune system Microglia mediate the immunomodulatory processes in the brain and play a crucial role in the neuroinflammation in PD, leading to chronic activation and releasing of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), which further increase the damage in neurons and promote disease progression 41

MASH/NAFLD: Given the liver fat-reducing effects of GLP-1 receptor agonism, orforglipron may be evaluated for metabolic dysfunction-associated steatohepatitis (MASH), a condition affecting an estimated 5-6% of the adult population for which effective oral therapies are urgently needed