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In general, these changes in hormone levels directly or indirectly contribute to the development and progression of CVDs mainly through the regulation of lipid metabolism, the impact of inflammatory factors, and the SASP

In addition, methamphetamine use disorders resulted in altered gut microbes, increased the relative abundance of pathogenic gut bacteria, and decreased the relative abundance of probiotic bacteria in mice, which was associated with systemic inflammation (203, 204)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Jamieson PM, Cleasby ME, Kuperman Y, et al