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It will be important to further determine whether these copper transporters at the plasma membrane play tumor type-specific roles in mediating copper uptake

Besides their function on inflammatory cells, experimental evidence emerge revealing a role of chemokine-driven cascades in neurons and neuronal function in the post-ischemic brain (de Haas et al., 2019)

First, its interplay with lipid metabolism: surplus pyruvate generated through glycolysis is converted to acetyl-CoA, which can enter lipid biosynthetic pathways and promote the synthesis of fatty acids, particularly PUFAs

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OS arises from a disruption in redox homeostasis, where an overproduction of reactive oxygen species (ROS) overwhelms endogenous antioxidant defenses, leading to oxidative damage to lipids, proteins, and DNA (Sies et al., 2024)