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With aging, the gradual accumulation of atherosclerotic risk factors, including oxidative stress, inflammation, dyslipidemia, and hyperglycemia, drives metabolic reprogramming in ECs, particularly in regions exposed to disturbed flow with OS, ultimately leading to EC dysfunction and atherosclerosis

Skin does not rebound darker, but results may gradually fade if contributing factors like sun exposure are not controlled

Obsessivecompulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent and distinctive obsessions and/or compulsions

One reviewer noted visible brightening and smoothing within a few weeks