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Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

Normal bioenergetic oxidation of substrates in the TCA cycle generates reduced dihydrolipoamide cofactors, whose oxidation by LpdA is coupled to reduction of NAD + to NADH

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10.1002/star.202000185 32 GuoW.ZhangQ.DuY.GuoJ.ZhaoT.BaiL.et al (2022)