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Medication Mechanism of Action Average Weight Loss Retatrutide Triple agonist (GLP-1, GIP, Glucagon) Up to 24% average weight loss over 48 weeks Semaglutide GLP-1 receptor agonist Up to 17% over 68 weeks Tirzepatide Dual agonist (GLP-1, GIP) Up to 25% over 52 weeks Retatrutide is used to help with weight loss

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Jewell D.E., Motsinger L.A., Paetau-Robinson I

In animal studies, this is the period where measurable increases in lipolytic activity appear (Ng et al., 2001)

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