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Hypoxic-glucose deprivation conditions can induce senescence in endothelial cells Unlike the previously mentioned natural aging models and progeria models, there is another common but often overlooked endothelial cell aging model: hypoxia-induced endothelial cell senescence

DOI:10.1371/journal.pone.0054456 98

2024;34(48) doi: 10.1002/adfm.202312038

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doi: 10.1002/adma.202200139

This cascade of mitochondrial damage, along with the impaired ability of mitochondria to regulate calcium homeostasis and bioenergetics, leads to further neuronal injury and death [157]