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Guidelines from the European Association for the Study of the Liver (EASL), the European Association for the Study of Diabetes (EASD), the European Association for the Study of Obesity (EASO), and regional hepatology associations recommend a stepwise algorithm: initial serum testing followed by liver ultrasound-based imaging techniques and fibrosis assessment [63, 76]

Observing the model after simulating several initial values and varying limiting agents, we found that pyruvate supply is the limiting substrate of the overall pathway

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