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Our results argue that inversely coupled low thiols/high ROS in mitochondria may trigger UPR, the elevated stress resistance, and increased lifespan (Fig
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GSH reduced GSH GSSG oxidized GSH CySSG mixed disulfide with cysteine GSSPr protein bound through a SH linkage cysteine equivalents were found to be 23% protein bound, with the remaining 77% distributed as follows: 5.9% cysteine, 83.1 % cystine, and 10.8% as the mixed disulfide with GSH
doi: 10.1016/j.mehy.2020.110469
& Gray, M
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