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In the brain, extracellular Glu content is maintained at extremely low levels because Glu may exert excitotoxicity in some neurons expressing NMDA-type glutamate receptors [163]

The correspondence between higher RRM2 expression and N stage further reinforces this notion

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Xue M, Zhang L, Yang MX, et al

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Different sources of MSCs have also been found to have differences in their immunological characteristics, as well as have different paracrine signaling and immune modulation abilities 92