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To achieve a therapeutic breakthrough in TBI, multifaceted approaches are probably required, including the development of new clinically relevant models, refinements of established models and functional tests, consideration of systemic insults and multimodality monitoring, identification of specific and sensitive biomarkers, and optimization of therapeutic dosing and timing of single and combination treatments, as well as improvement in clinical trial design and operation

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Recent clinical trials with once-weekly injection of an amylin receptor activator cagrilintide [10] alone and cagrilintide combination with a GLP-1 receptor agonist semaglutide showed a significant 10 to 17% body weight reduction [11,12]

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