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The first hiPSC-based model of SQT1 was reported by El-Battrawy et al., using hiPSC-CMs derived from a patient with SQT1 (SQT1hiPSC-CMs) with the KCNH2 N588K mutation, which reproduced the single-cell phenotype of SQT (El-Battrawy et al., 2018)

7 In total, 30 of 73 patients were reported to have experienced cholestatic/mixed picture liver injury

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Understanding metabolic dysfunctions in ASD and identification of the specific markers, e.g., glutathione, vitamin E, tetrahydrobiopterin, and antioxidative enzymes such as glutathione peroxidase, paraoxonase, and superoxide dismutase, may direct ASD treatment toward specific metabolic disturbances [23,28]
