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If an antioxidant is not present in sufficient quantity to neutralize ROS, oxidation of biomolecules, like lipid peroxidation, protein damage (carbonylation of aminoalkanoic acid residues), oxidation of single DNA and RNA nucleotides, enzyme inhibition, and activation of apoptosis, will occur (Gill and Tuteja, 2010)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 315.Ghalia A.H.A., Fouad I.M

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Byun, in a study examining the effects of procyanidin C1 on rat aortic endothelial cells (RAECs), found that procyanidin C1 induced hyperpolarization dependent on potassium channels, enhanced intracellular calcium influx, and boosted NO production