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Current evidence suggests that Time-Restricted Eating may help realign the biological clock and reduce the risk of metabolic diseases (Pickel and Sung, 2020)and the type of CR (Takahashi et al., 2018) may also influence the expression of circadian clock genes

Epigenetic modifications, such as increased methylation and expression of the pseudogene PTENP1, occur with age, possibly as a protective mechanism against malignancy [43]

doi: 10.1371/journal.pone.0252822 86 LiMGaoJTangYLiuMWuSQuKet al

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The 2HG content of experimental samples was determined by interpolation using 2HG peak areas measured in the standards
