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Further studies with increased sample size and efforts to identify the metabolite markers by a more sensitive complementary method such as mass spectrometry can be used to further corroborate these findings

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326 In addition, the role of arginine methyltransferase (PRMT) in the regulation of tumorigenesis and development has also received extensive attention, and a variety of PRMT inhibitors have shown good anti-tumor activity in vitro and animal models, and a variety of drugs targeting type I PRMT and PRMT5 have been tested

Safety, pharmacokinetics, biomarker response and efficacy of E6742: a dual antagonist of Toll-like receptors 7 and 8, in a first in patient, randomised, double-blind, phase I/II study in systemic lupus erythematosus