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NaBPC157 (without effect on basal normal values) compared with L-arginine has both a mimicking effect (impaired L-NAME-blood pressure increase, applied prophylactically and decreased already raised L-NAME values, given at the time of the maximal L-NAME-blood pressure increase (i.e., 10 minutes after L-NAME)) and a preventative activity (L-arginine-induced moderate blood pressure decrease was prevented by NaBPC157 pre-treatment)

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During freeze-drying, the peptides are gently frozen and placed under low pressure so the water turns straight from ice into vapor

CONCLUSIONS: CagriSema presents clinically relevant reductions in BP across a wide range of participant subgroups, including those with resistant hypertension

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