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It is stored in high concentrations in tissues with high metabolic demand, including the liver, brain, eyes, heart and skeletal muscles

Disorders have been described in EMP, HMP, the Rapoport-Luebering cycle, the glutathione pathway (Figure 23-2), purine-pyrimidine metabolism, and methemoglobin reduction

Notably, LAMP proteins, especially LAMP-2, are essential for lysosomeautophagosome fusion

multiple unpaired t-tests, corrected for multiple comparisons using the HolmSidak method)

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