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6.2 Stability and limitations of clinical translation The most commonly modified bacterium*Escherichia coli* Nissle 1917exhibits significant variability in colonization capacity across individuals during therapeutic administration

Individuals scheduled for surgery should discontinue ashwagandha at least two weeks beforehand, as it may interact with anesthesia and affect blood pressure during procedures

doi: 10.1042/bj20031327 132 WangX.ProudC

Supplementation: For those with confirmed deficiency or at high risk, B12 supplementation is recommended

on days -3, -2 and -1 before infection and 7 days after infection

Blood 104 , 31363147 (2004)