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Serafini V

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Under oxidative stress, Nrf2 dissociates from kelch-like ECH-associated protein-1 (Keap1), translocates to the nucleus, and the activated Nrf2 induces the expression of various endogenous antioxidant enzymes [10]

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Notably, lactylation of the solute carrier family 25 members, Slc25a4 and Slc25a5, was exclusive to the CIRI group, while lactylation of voltage-dependent anion channel protein 1 (Vdac1) was detected solely in the control group [61]