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You can continue using it, but expect reduced efficacy and consider adjusting dosing schedules accordingly if your research protocol allows

Furthermore, it has also been shown that diabetic patients exhibit macrovascular changes and dysregulation of BBB permeability that further facilitates robust inflammatory response and stroke (BBB dysfunction in ischemic stroke)

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Encouraging results extend to the neoadjuvant setting, where a PD-1/LAG-3 bispecific antibody combined with other ICIs resulted in superior outcomes in patients with resectable melanoma [344]