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CLIC proteins contain Grx-like active site motiv, Cys-Pro-(Phe/Ser)-(Ser/Cys), present also in O-class GSTs [208,220,221]

While IGF-1 LR3 was engineered for extended half-life and systemic activity, IGF-1 DES follows the opposite strategy: very short half-life (20-30 minutes) but extreme potency at the site of injection
It holds onto the organ of longevity, our muscles

pmid:22534974
Because subcutaneous adipose tissue has a lower density of growth hormone receptors, it may not be as readily mobilized by growth hormone-induced lipolysis