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Depending on the relative loss of water and solutes from extracellular fluids, dehydration can be hypertonic (water loss concentrates extracellular water), hypotonic (sodium loss dilutes extracellular water) or isotonic (water and sodium losses with no change in concentration)

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PLoS ONE 4 , e7798 (2009)

Notably, enzymes such as aldehyde dehydrogenases (ALDHs) and glutathione S-transferases (GSTs) maintained relatively high expression at Day 45, possibly supporting metabolic adaptation to a diverse cellular environment

The mechanism of gemcitabine-induced TMA has not been elucidated

AFL General Counsel Andrew Dillon said on Wednesday ASADA's advice was consistent with a WADA statement in April