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Access this article Similar content being viewed by others Abbreviations GSH: l--glutamyl-l-cysteinyl-glycine (glutathione) GSSG: Oxidised form of glutathione DEM: Diethylmaleate H 2 S: Hydrogen sulfide IL-6: Interleukin-6 JNK: c-Jun- N -terminal kinase MAPK: Mitogen-activated protein kinase NF-B: Nuclear factorB SAPK: Stress-activated protein kinase TNF: Tumour necrosis factor xCT: Subunit of the x c cystine-glutamate exchanger References Aitken SM, Kirsch JF (2005) The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity

doi: 10.1080/01902148.2020.1753266 56 KawaiT.AkiraS

NAC is a membrane-permeable Cys precursor for GSH synthesis

The Stanford PNAS study noted striking sex-specific differences in this regard, finding that male ME/CFS and Long COVID patients exhibited pronounced mitochondrial lipid oxidative damage mediated by a failure in Glutathione Peroxidase 4 pathways