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Furthermore, a study revealed that liver-specific Zip8 KO mice exhibited significant decreases in systemic Mn levels under both Mn-rich and Mn-depleted conditions, indicating that hepatic ZIP8 mediates Mn reabsorption from bile to help maintain systemic homeostasis (Powers et al., 2023)

doi: 10.1074/jbc.M405878200

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The peptide also demonstrates protective effects against haloperidol-induced sphincter dysfunction and oxidative stress in both sphincter tissue and brain regions

It has been reported that in age-related nuclear cataracts, the vast majority of cysteine residues and approximately 5060% of methionine residues of lens proteins are oxidized [25]