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doi: 10.3389/fonc.2022.888699 119 CaoLWangYLiuJBaiXChiX

In CKD, uremic toxins (e.g., indoxyl sulfate) synergize with iron overload to suppress GPX4, further enhancing ROS-mediated eryptosis ( 4 The role of eryptosis in patients 4.1 The role of eryptosis in non-dialysis-dependent patients Eryptosis, the programmed death of erythrocytes characterized by PS exposure on the cell membrane, has emerged as a critical contributor to renal anemia in non-dialysis-dependent chronic kidney disease (NDD-CKD), with estimated glomerular filtration rate (eGFR) identified as its key determinant ( r 2 = 0.22) and the NDD-CKD subgroup ( r 2 = 0.10)

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Neurosci Res 140:4352 Ambrogini P, Torquato P, Bartolini D et al (2019) Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: the role of vitamin E [J]

Endocr Rev 39(5):760802 Zhang H et al (2021) PPARalpha agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway