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some tumors rely on it for survival under high oxidative pressure, while deficiencies in healthy cells might promote tumor initiation through DNA damage

Long-term use is frequently associated with debilitating motor complications, such as dyskinesias and fluctuations in symptom control [6]

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The PYCR2 gene is located on chromosome 1q42.12 and is composed of 7 exons that generate two alternatively spliced mRNAs that encode proteins of 320 amino acids (isoform 1) and 246 amino acids (isoform 2)

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Similarly, the mitochondria-targeted SOD mimetic mito-TEMPO effectively protected against APAP hepatotoxicity36