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Pathways of Hepatic Oxalate Synthesis and Their Regulation
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Liver injury caused by acetaminophen is initiated by cytochrome P450 (CYP)-mediated bioactivation to N -acety- para -benzoquinoneimine (NAPQI), which is a chemically reactive intermediate that is formed at high levels following overdosage and triggers a complex cascade of events, which ultimately result in hepatocellular necrosis (Hinson et al
The molecule is found in the food supply and in the human body where it acts as an antioxidant
Disclosure The authors report no conflicts of interest in this work
Collagen synthesis pathways demonstrate coordinated regulation under dual compound treatment
