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The demyelination observed in this study in the cuprizone pellet group is in the early phase at 3 weeks, and a longer period of exposure to cuprizone of 5 weeks may have resulted in a more severe demyelinating effect 39
if further testing is required, this should be by a rheumatologist, who will look for (amongst other things) lupus, Sjogren's, connective tissue disease, rheumatoid arthritis...and many other autoimmune conditions too
It also inhibits gut motility and secretion and regulates food intake
The following databases were searched MEDLINE via Pubmed, Embase, Scopus, CINAHL for the period 1978 to June 2019
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The compound's primary target, NNMT, sits at a critical metabolic intersection where NAD+ precursor availability meets cellular methylation capacity
