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It is endogenous for the growth hormone secretagogue ligand (GHS-R) and was the first circulating hormone shown to stimulate weight gain and eating

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The X-box-binding protein-1 (XBP1), spliced and activated by IRE1, is downregulated in glomerular mesangial cells, weakening the inhibitory effect on the phosphatase and tensin homolog (PTEN)/Akt pathway, thereby aggravating kidney damage

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[DOI] [PubMed] [Google Scholar] Maughan S.C., Pasternak M., Cairns N., Kiddle G., Brach T., Jarvis R., Haas F., Nieuwland J., Lim B., Mller C., Salcedo-Sora E., Kruse C., Orsel M., Hell R., Miller A.J., Bray P., Foyer C.H., Murray J.A.H., Meyer A.J., Cobbett C.S