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SPIOMET4HEALTH-efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, four-arm, parallel-group, phase II clinical trial

Beyond these findings, clinical outcomes data in this population are limited, underscoring the gap between pharmacokinetic concerns and available evidence

however, the underlying mechanism is incompletely understood

Proc Natl Acad Sci USA 116:2599126000 Kirby J, Halligan E, Baptista MJ et al (2005) Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS

Lynch has uncovered the biochemical reasons why some people tolerate glutathione beautifully while others dont

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