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Melatonin counteracts this, and it also reduces the intestinal permeability caused by nonsteroidal anti-inflammatory drugs (NSAIDS) in animal models.[64] Some individuals who have gastroesophageal reflux disease (GERD) and are bothered by symptoms when they are supine may benefit from a low dose (0.5-3 mg) of melatonin at bedtime

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Solis-Cruz B., Hernandez-Patlan D., Petrone V.M., Pontin K.P., Latorre J.D., Beyssac E., Hernandez-Velasco X., Merino-Guzman R., Owens C., Hargis B.M., et al