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T.et al (1997)

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The first reaction is catalyzed by tryptophan hydroxylase (TPH-1), which requires L-tryptophan, tetrahydrobiopterin (BH4), and O 2 as co-substrates, and has ferrous ion (Fe 2+ ) as an activator

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The PUFAs are expected to facilitate such effects via modulating TRP channels [115]

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