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Moreover, cellular susceptibility to ferroptosis is closely linked to iron metabolism, including its import, export, utilization, and storage 9, 10, 14

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For this interaction to occur, the structural requirement in the enzyme is the presence of a nucleophilic amino acid side-chain close to the glutathione-docking motif and in a crucial position to interact with the electrophilic motif of glutathione acrylate, as shown in Scheme 9

The vitamins, such as B1, B2, C, B6, B12, folic acid, and biotin, are then prepared in a sterile, pharmaceutical-grade injectable solution