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"Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study"
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Mild headache or dizziness : This normally passes quickly

Persistently high readings without supplements can indicate liver, kidney, blood, or inflammatory conditions, so followup evaluation may be recommended
True B12 toxicity symptoms are rare but may include skin reactions, mild gastrointestinal disturbances, and headaches, particularly with injections

Together, these multiple mechanisms contribute to the efficacy of daratumumab, which was proven in the subsequent clinical trials as an effective and durable antitumor drug in MM patients
