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Retina immunofluorescence Retinas were dissected, cleaned and dehydrated in 100% ethanol for 30 min followed by permeabilization with 1% Triton X-100 for 30 min at RT
The calculation is: PTE = 0.5 (IND period) + 1 (NDA review period), subject to a cap of five years and a maximum remaining patent term of 14 years post-approval
Proc Soc Exp Biol Med 115:725728 Arisawa T, Harata M, Kamiya Y, Shibata T, Nagasaka M, Nakamura M, Fujita H, Hasegawa S, Nakamura M, Mizuno T, Tahara T, Ohta Y, Nakano H (2006) Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers

Too much signal and you waste money without additional benefit, the response curve plateaus rather than climbing indefinitely

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Changes in gut motility signaling