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IL-1, for example, increases AAV transduction efficiency in human synovial cells, suggesting that the OA microenvironment may be leveraged to improve delivery (183)

Diammonium glycyrrhizinate supplementation in mice lowers BSH-enriched bacteria, increasing taurine-conjugated BAs, inhibiting ileal FXR-FGF15 feedback signaling, suppressing CYP7A1 expression, altering the BA profile, and improving metabolism, including lowering blood glucose and insulin levels, enhancing insulin sensitivity, reducing hepatic steatosis, and resisting weight gain [83]

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